Predicting nodal status in male breast cancer using mammogram based radiomic metrics
Original Article

Predicting nodal status in male breast cancer using mammogram based radiomic metrics

Arjun Moorthy1^, Bino Varghese2, Shakila Rajack1, Ronald Korn3, Steven Cen2, Brenda Moorthy4, Vinay Duddalwar2

1Arizona Center for Cancer Care, Phoenix, AZ, USA; 2Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; 3Honor Health Research Institute at Virginia G. Piper Cancer Center, Scottsdale, AZ, USA; 4Comprehensive Breast Center of Arizona, Peoria, AZ, USA

Contributions: (I) Conception and design: A Moorthy, B Varghese, V Duddalwar; (II) Administrative support: A Moorthy, B Varghese, V Duddalwar; (III) Provision of study materials or patients: B Moorthy; (IV) Collection and assembly of data: S Rajack, B Varghese, A Moorthy; (V) Data analysis and interpretation: S Cen, B Varghese, A Moorthy, R Korn; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.

^ORCID: 0000-0003-2162-7913.

Correspondence to: Arjun Moorthy. Department of Breast Surgery, Arizona Center for Cancer Care, 19646 N 27th Ave., Phoenix, AZ 85027, USA. Email:

Background: Axillary lymph node (ALN) status is one of the most important prognostic factors. Staging based on tumor size and nodal status are good predictors of survival. Accurate preoperative assessment of nodal status currently could be improved. All current imaging analysis depends on the operator observation of a lesion. Radiomics utilizes assigning a characteristic to each pixel in a tumor and captures data not seen by the naked eye. Patterns within a tumor that make nodal metastasis possible are recognized. Therefore, we wanted to know if radiomics of a tumor on mammography could predict nodal status. There is a suggestion this can be done in female breast cancer (FBC). We wanted to ask this question in male breast cancer (MBC) patients.

Methods: We aim to test the feasibility of using radiomic analysis on diagnostic mammograms in MBC patients to predict axillary nodal status based upon imaging feature of the primary tumor alone. In this retrospective study, 60 MBC subjects (mean, 67.4 years) with mass lesions detected on digital mammography (tumor size range, 0.7–4.5 cm) were included. Twenty-seven subjects (45%) had pathologically proven node positive disease. All primary tumors were digitally segmented from digital mammograms and subsequent radiomic analysis was performed using The Cancer Imaging Phenomics Toolkit (CaPTk). Independent t-test or Wilcoxon rank sum test was conducted to filter signals associated with nodal status using an alpha value of 0.05.

Results: A total of 276 out of 1,360 radiomic metrics were found to be significantly (P<0.05) different between the two groups. The best performing metrics were histogram and intensity based radiomic features (first-order texture approaches).

Conclusions: We conclude that it is feasible to use radiomics-based texture metrics in MBC patients to potentially differentiate patients with pathological node negative vs. pathologically node disease based upon analysis of the primary tumor lesion. If validated, this approach may help better select patients for lymph node dissection and/or neoadjuvant endocrine therapy.

Keywords: Radiomics; male breast cancer (MBC); lymph node status; mammograms

Received: 11 September 2020; Accepted: 22 January 2021; Published: 30 March 2021.

doi: 10.21037/abs-20-103


Male breast cancer (MBC) is a rare disease, comprising less than 1% of all breast cancer cases in the USA and less than 0.1% of cancer related deaths in men (1). While the incidence of female breast cancer (FBC) has been decreasing since the year 2000, the juxtaposed incidence of MBC has risen by 26% over the last 25 years. Dedicated breast cancer research in males would be valuable (2). Some of the hurdles include the lack of sizable patient cohort from prospective studies owing to the rarity of MBC and the frequent exclusion of male patients from breast cancer clinical trials (1). Therefore, guidelines in the treatment of MBC are extrapolated from the data generated from FBC trials or based on small retrospective cohorts (2). Further, data derived from retrospective studies are observational and hence subjective (2). Nevertheless, nodal status appears to remain a key prognostic discriminant and is important for tailoring treatment in MBC (3).

Currently, imaging is used as a non-invasive method in a preoperative setting in the evaluation of MBC. Diagnostic mammography remains the mainstay of imaging but ultrasonography (US), computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET) can play a key role in diagnosis and staging.

Despite recent advances in imaging there remains a low diagnostic sensitivity for axillary lymph node (ALN) involvement resulting in understaging of the disease even when lymph nodes are visible on imaging (Figure 1) (4). A systematic review estimated the average sensitivity for positivity of US in patients with nonpalpable axillary nodes to be 44–61% and specificity for positivity at 75–86% in all patients (5). Currently, if clinical and US evaluation suggest nodal metastases on the basis of size or abnormal morphology, US-guided biopsy [fine-needle aspiration cytology (FNAC) or core biopsy] of abnormal nodes is undertaken, which detects 45% of metastases (5). However, there are a significant number of false negatives.

Figure 1 Example of MBC masses in the subareolar region of the right breast. Example of two patients with IDC. Panel (A) is a 48-year-old male with palpable subareolar mass, core biopsy shows grade 3 IDC ER79%/PR12%/HER2/neu 0 clinical stage T2N0Mx. The patient underwent mastectomy with lymph node sampling. The pathology demonstrated a 4.1 cm IDC with negative margins, 1 positive SLN and completion axillary node dissection shows 14 nodes negative. Final pathological diagnosis was T2N1M0 grade 3 IDC. Panel (B) is 87-year-old male with clinical history of subareolar mass and normal appearing lymph nodes (arrows). A core biopsy shows grade 3 IDC ER95%/PR80% and HER2/neu 0 clinical stage T2N0M0. The patient underwent mastectomy with lymph node sampling which revealed a 3.3 cm negative margins and four sentinel nodes negative. Pathologic diagnosis was T2N0M0 grade 3 IDC. MBC, male breast cancer; IDC, invasive ductal carcinoma; SLN, sentinel lymph node.

The current study evaluates only the primary tumor to identify radiomic metrics capturing a variety of tumor phenotypes such as size, shape and radiological texture from mammograms which could predict the presence of nodal metastases. We report a reasonable performance [area under the curve (AUC) =0.71] in discriminating pathologically node negative vs. node positive male patients. Currently, we are limited by no availability of nodal imaging in a large proportion of our retrospective cohort. However, we hope to address this in future and prospective studies. Therefore, any method that improves upon a more accurate detection of nodal disease would be important. Accurately assessing pathological nodal status prior to surgery can help clinicians optimize treatment strategies by identifying patients who may be eligible for neoadjuvant chemotherapy/endocrine therapy or even omission of sentinel node biopsy and enrollment in clinical trials.

Radiomics is an emerging field of quantitative medical imaging that involves converting medical images into mineable and scalable high-dimensional data sets derived primarily from standard of care imaging. Predictive models based on the extracted datasets along with additional clinical, pathologic and laboratory data have been shown to improve upon the accuracy of cancer diagnosis, prognosis and prediction (6,7). The radiomic process involves lesion segmentation from clinically obtained imaging, feature extraction, and finally model building. The radiomic features that are extracted reflect the heterogeneity of the tumor by calculating pixel intensities and their spatial distribution over a region of interest (ROI). Both quantitative and mathematical descriptions of the spatial distribution of signal intensities are referred to as texture analysis.

Numerous radiomic studies in FBC using mammography and breast MRI have been published (8-11). Several studies have established MRI imaging features combined with radiomics can be used to predict molecular subtypes, luminal A (P=0.004), HER2/neu enriched (P=0.00277) and basal like (P=0.0117) (11) and predict imaging biomarkers predicting pathways associated with survival (6). Textural features obtained from mammograms have also been used to predict BRCA1/2 probability from textural parenchymal differences not detectable by standard radiologic interpretation (9).

There are several studies evaluating mammography, MRI and US to evaluate axillary node status in FBC. For example, Tan et al. (12) developed a mammogram-based radiomics nomogram by integrating radiomic metrics with clinical risk factors to predict preoperative axillary metastasis and reported an AUC 0.876 and 0.862 in the primary and validation cohorts. Dong et al. (13) showed that using radiomics in DWI and joint fat sat T2 MRI can preoperatively predict sentinel lymph node (SLN) metastasis in FBC with an AUC of 0.80 in the validation set. Using deep learning in combination with radiomic metrics from the US of 1,280 patients breast cancer patients Guo et al. (14) identified patients with positive sentinel node metastasis with a sensitivity of 98.4% and those without metastasis with a 97% negative predictive value. To our knowledge, there have been no studies evaluating omitting sentinel node biopsy based on radiomic nodal assessments.

Radiomic features have been used to classify mammographic breast parenchymal complexity. These radiomic features in combination with breast density and body mass index (BMI) have been shown to help stratify breast cancer risk assessment (15).

To our knowledge, there has been no published radiomic analysis in male patients with breast cancer. Therefore, the aim of this study was to develop a mammography-based radiomics platform by performing a retrospective evaluation of the radiomics (tumor texture, size and shape metrics) of primary lesions in subjects MBC. Specifically, we wanted to explore the feasibility of using radiomic signatures from the primary lesion to discriminate pathologically node positive vs. node negative MBC patients based upon diagnostic mammograms.

We present the following article in accordance with the Materials Design Analysis Reporting (MDAR) reporting checklist (available at


Patient data

The retrospective study was conducted in accordance with the Declaration of Helsinki (as revised in 2013). The study was approved by the Western Institutional Review Board to exempt the ethics review with the exemption number (B4-Exemption-Moorthy). Informed consent was also waived. A total of 75 MBC patients, from our breast cancer database, who underwent surgical treatment at a single institution (Arizona Center for Cancer Care) between 2009–2020 were included in this study. The inclusion criteria included men diagnosed with a pathologically confirmed breast cancer with access to their 2D digital mammograms prior to their surgical intervention with complete pre surgical and surgical information. Patients in whom the mammograms were not available (n=15) were excluded. All digital mammography images were obtained from the picture archiving and communication systems (PACS). Clinicopathologic and immunohistochemical factors from core biopsy were acquired from the prospectively maintained center database. Demographic variables included age, sex, and ethnicity. Relevant prior clinical history of cancer was also recorded. Clinical and pathological factors such as clinical T stage, clinical nodal status, estrogen receptor (ER), progesterone receptor (PR), Ki67, human epidermal growth factor receptor (HER/2-neu), surgical management, adjuvant therapy, local regional recurrence rate, disease free survival and overall survival data were collected.

Mammography acquisition

All patients included in the analysis had 2D digital mammograms [craniocaudal (CC) and mediolateral oblique (MLO)]. All digital mammograms were acquired per the site’s standard of care procedures for exposure settings and the images were stored in PACS in DICOM format. De-identified images were curated and archived onto an open source image segmentation software for segmentation and feature extraction as described below.

Mammographic inspection and tumor segmentation of tumor lesions

A single breast specialist (BM) with over 15 years of experience in mammography reviewed all images. The reader was NOT blinded to the side or the location of the tumor. The mammographic images (CC and MLO views) from all 60 subjects (10 were clinically node positive, while 50 were clinically node negative) were available for evaluation While a subset of patients (n=7) had a 3D mammogram, a 2D radiomic analysis was conducted to maximize the cohort sample size. Consequently, the ROI was marked on the 2D component of the mammogram or reconstructed 2D mammogram. All tumors were detectable on 2D mammograms. This cohort was acquired retrospectively before 3D mammo was widely available. Cancer Imaging Phenomics Toolkit (CaPTk) can be used to mark ROI on 3D images. A 3D dataset was not available for all the cases included in this cohort. Though 3D tomosynthesis is the primary modality being used for screening in many centers, there are logistical issues that arise when using it in radiomics. As this was a multicenter study, there was no consistent imaging protocol that was adopted. While 3D evaluation may improve the accuracy of radiomic evaluation, in some instances 2D evaluation may produce similar accuracy (16-18).

All had the presence of the mass lesions (primary tumor) on mammography. Any features such as suspicious calcifications, skin thickening, or nipple retraction were not captured unless there was an overlap with the segmented primary tumor. Any mammographically suspicious lymph nodes were not included in the imaging. For each patient, a single lesion was identified on both the CC and MLO view mammograms for radiomic analysis.

The tumor lesions on the mammograms were segmented using a 2D ROI that was placed around the whole lesion in both the CC MLO view using ITK-SNAP (open source software; for image segmentation (19,20). The resultant ROIs from the ITK-SNAP segmentations were saved for transfer, processing and radiomic analysis (Figure 2). According to Huang’s and Dong’s study (13,21), a radiomics signature was concluded by radiomics features that extracted from primary tumor, which was used to predict lymph nodes metastasis and show a significant performance. Therefore, it is reasonable that we choose the primary tumor as the segmentation region. In future and prospective studies when we have access to dedicated nodal imaging, we will address this specific issue.

Figure 2 A typical radiomics workflow comprises of three main stages. Stage 1: image acquisition; stage 2: lesion segmentation and/or ROI marking (highlighted in red); stage 3: feature extraction

The evaluation of the axilla by mammography can be limited due to the body habitus of most men, lack of the ability to identify the SLN amongst the number of potentially visualized nodes by mammagraphy and lack of specific guidelines to include the entire axilla during mammographic examinations. Therefore, we were unable to directly address this question from the reviewer. This topic may be better addressed in the future using MRI or US where the entire axilla could be visualized.

Radiomics analysis

CaPTk (22) is an open source software platform, ( that was used for feature extraction of ROIs obtained following ITK-SNAP extraction of tumor lesions. These segmented ROIs were then transferred to CaPTk for radiomics analysis (Table 1). While CaPTk can perform both 2D and 3D radiomic analysis, we performed only 2D radiomic analysis. The radiomic metrics quantifies the characteristics of the region of the interest such as the spatial distribution of the grey-levels making the ROI (shape/size) and the complex relationship between pixels/voxels making up the ROI (texture) using sophisticated data characterization algorithms. Some of the key metrics featured within the CaPTk radiomics platform include first-order statistical metrics of texture such as intensity, histogram; first-order statistical metrics of morphology such as shape, size; second-order statistical metrics of texture such as grey level co-occurrence matrix (GLCM), grey level size zone matrix (GLSZM), grey level run length matrix (GLRLM); and higher-order statistical metrics of texture such as local binary patterns (LBP), Lattice-transformation etc. First-order statistical metrics quantify only the intensity of the signal within a ROI. First order statistical features describe the distribution of individual voxel values without concern for spatial relationships. These are histogram-based properties reporting the mean, median, maximum, minimum values of the voxel intensities on the image, as well as their skewness (asymmetry), kurtosis (flatness), uniformity, and randomness (entropy).

Table 1
Table 1 Radiomic features evaluated on diagnostic mammograms in 60 MBC subjects
Full table

These radiomic features assess different imaging characteristics. They may be representative of or be surrogates for specific biologic processes but these would also be dependent on clinical and patient specific factors. Radiomics therefore may potentially enhance or nuance the clinical and pathological data available for treating physicians to make patient specific decisions.

Second-order statistical metrics take into consideration the intensity as well its spatial orientation, location within a ROI. Higher-order metrics transform the image to provide additional information regarding frequency, assessment at multiple levels (local versus global assessment). Post-radiomics analysis, all results were exported in comma separated value (.csv) format for radiomic analysis and correlation with pathological node positive and node negative status in all 60 subjects with a confirmed diagnosis of invasive breast carcinoma.

Statistical analysis

An independent t-test or Wilcoxon rank sum test were used, depending on data normality, to compare radiomic metrics that would produce statistically notable differences between pN0 (node negative) and pNmic (node with a micromet defined as tumor <2 mm)/N1a (tumor spread to 1–3 lymph nodes) using MLO and CC mammograms, separately. Graphical approach was used to illustrate the pattern of radiomic signals with differences between clinical findings. Since the main purpose of this study is to discover signal patterns by radiomics categories, we have used unadjusted P value to filter features for graphical illustration. Percent of features with unadjusted P<0.05 under each radiomic categories were calculated. ElasticNet was used to further explore important predictors and the overall prediction accuracy. Leave-one-out (LOO) procedure was used to validate performance. The predicted probability from LOO was used to calculate AUC. We have counted number of times a feature been selected by ElasticNet as the important predictor from each iteration of LOO, and then rank all features by this count. SAS9.4 (SAS, NC, USA) was used for statistical analysis.


A total of 60 patients met the inclusion criteria. The cohort characteristics are found in Tables 2,3. The final cohort included 28/60 (46%) patients who were pathologically node positive and 32/60 (53%) patients who were pathologically node negative (Table 1). Among the tumors, 41/60 (68%) were low-grade (Bloom Richardson Score grades 1–2) and 17/60 (28%) were high-grade (Bloom Richardson Score grade 3). Based on histopathology by IHC, 30/60 (50%) were luminal A and 25/60 (42%) were luminal type B. Five patients had indeterminate histopathology. Mean age was 66.2 years (range, 40–91) years. Mean tumor size was 1.9 (range, 0.7–4.5) cm. Node positive patients include patients who were pathologically N1mic, N1, N2, N3. Our cohort included 5 patients with N1mic, 16 patients with N1, 3 patients with N2 disease, and 4 patients with N3.

Table 2
Table 2 Characteristics of the patients collected, including race, side of cancer, location of the cancer, marital status, 1st degree relatives with cancers that could be related to a genetic mutation, genetic testing results and if the patients had recorded personal history of any cancer
Full table
Table 3
Table 3 Patient characteristics of the final cohort of patients (n=60)
Full table

The ElasticNet based receiver operating characteristic (ROC) curves showed an AUC of 0.52; 95% CI (0.37–0.68) and 0.71 95% CI (0.57–0.85) in the testing cohort to differentiate patients with pathological node negative vs. pathologically node positive disease based upon analysis of the primary tumor lesion (Figure 3).

Figure 3 The ROC curve for the ElasticNet model run for the MLO view features, and the AUC of the curve is around 0.71. ROC, receiver operating characteristic; AUC, area under the curve.

Radiomic results

The tumor characteristics using radiomic metrics available in CaPTk software of highest significance is shown in Table 4. These metrics were derived from the MLO and CC mammogram of each patient. For clarity purposes, we only reported those variables that were statistically significant (P<0.05). The violin plots in Figures 4,5 show different distributions in radiomic properties between pN0 and pN1, respectively, and these distributions are similarly illustrated with boxplots in Figures S1,S2.

Table 4
Table 4 Radiomic signatures of significance that distinguish tumors from node + vs. node – disease
Full table
Figure 4 Sample plots of radiomic metrics extracted from CC mammogram that showed significant (unadjusted P<0.05) differences between pN0 and other nodes. CC, craniocaudal.
Figure 5 Sample plots of radiomic metrics extracted from MLO mammogram that showed significant (unadjusted P<0.05) differences between pN0 and other nodes. Interestingly, all of them belonged to first-order texture metrics. MLO, mediolateral oblique.

Interestingly, all of them belonged to first-order texture metrics.

A total of 276 out of 1,360 radiomic metrics were found to be significantly (unadjusted P<0.05) different between the two groups. The best performing metrics were mostly (80%) based on first-order texture approaches i.e., histogram and intensity (Table 4).


The incidence of MBC has been rising over the past few decades (24). There is an increasing appreciation of differences in the tumor biology of FBC versus MBC (25), thereby highlighting the need for studies focused on this unique population. Currently, there is a lack of studies supporting the treatment recommendations for MBC. What is clear is that after correcting for confounding features, MBC patients have a worse prognosis, stage for stage (1). Therefore, it is imperative to focus on this subset of breast cancer patients and consider tailored strategies such as neoadjuvant therapy or omitting sentinel nodes evaluation, if feasible. ALN status is an important factor in developing a personalized treatment plan for female patients with breast cancer (7), and since 40% of MBCs have pathological detected nodal involvement (1), it would optimize management to reliably know nodal status at the time of diagnosis.

Non-invasive prediction of ALN metastasis preoperatively has significant clinical impact. Currently, ultrasound has a specificity for positivity of 75–86% in all patients and is non-invasive. However, an US study identifying a suspicious node would prompt a US guided biopsy which requires additional time delay due to the need for another appointment and a false negative rate up to 30% (16).

Surgery is still needed to definitively confirm the status of the ALN if preoperative nodal status is not established. These are invasive procedures and associated with sequelae such as seroma, arm pain, infection and lymphedema (26,27). Sonographically guided biopsy of nodes has variable reliability (28). Since mammography is already used as a diagnostic tool and current workflow would be enhanced, we chose mammography for our study.

This study explored the radiomic differences between tumors in pN0 vs. non-pN0 subjects. We identified 276 out of 1,360 radiomic metrics to be significantly (P<0.05) between these two groups of patients. These radiomic features indicates that the distribution of grey levels within a ROI (indicative of radiological texture) is different in primary tumors that are node negative versus those that are node positive. We have reported the predictive value of radiomics in terms of the AUC metric in Figure 3. We report an AUC of 0.71 in discriminating pathologically node negative vs. node positive male patients using radiomic-metrics derived from mammograms. Genomic information was not available for this cohort of patients therefore not evaluated in this study.

Of the 276 radiomic metrics that were found to be significantly (P<0.05) different between the pN0 and non-pN0 subjects, the best performing metrics were based on first-order texture histogram and intensity. The observation of first-order metrics to be significantly different between the two groups i.e., pN0 vs. non-pN0 nodes is encouraging, as first order metrics are easy to implement in the existing clinical workflow without any additional computational or technical complications. A number of clinical imaging software by default provides histograms or ROIs from where these metrics can be easily derived.

To improve the generalization ability and optimize the model, we used the ElasticNet method in conjunction with LOO cross-validation to build a prediction model. Our findings indicated that our prediction model has a moderate discrimination power (AUC =0.71) to distinguish between patients with pathological node negative vs. pathologically node disease based on radiomic analysis of the primary tumor lesion using their MLO view, the performance of the prediction mode using the CC view was comparatively lower (AUC =0.52). Interestingly, all the CC and MLO-based radiomic metrics that showed significant difference between pN0 and other nodes on the MLO and CC mammograms, respectively (Table 4), also were highly ranked as important variables that dictated the performance of the ElasticNet -based prediction model. This observation increases our confidence in the reliability of important predictors to discriminate patients with pathological node negative vs. pathologically node disease based on radiomic analysis of the primary tumor lesion.

There were different radiomic features in the tumors between the CC and MLO views which can be explained by the fact that imaging features can be different in CC and MLO views influencing the textural features that are significant. In their study (29), exploring mammographic structural features (texture/parenchymal pattern) jointly for the improved risk segregation of screening women, Winkel et al., reported that a more precise density measures were achieved when mentally fusing two projections (CC and MLO) compared with assessing only a single projection of the breast, which aided in improved risk assessment. Therefore, it is possible that the significant texture metrics assessed from the two different views may be different, due to the variation in the breast tissue orientation in the different views. Further, creating a separate model using CC and MLO data separately had the increased impact of our study, as researchers with only CC or MLO view could still benefit from our results.

Zheng et al. demonstrated that deep learning radiomics could yield a 90% accuracy of predicting metastatic ALN in early stage FBC using ultrasound and shear wave elastography via deep learning approaches (8). Using a radiomics signature of 10 radiomic metrics, one non-wavelet feature and nine wavelet features, which were significantly related to lymph node metastasis, Yang et al., showed the feasibility of using mammogram-derived texture metrics in preoperatively predicting lymph node status (30). It is encouraging to see the similar observations in MBC in our current study as well.

For MBC, standard treatment has been mastectomy with axillary node dissection for clinically node positive patients or sentinel node biopsy with selective axillary dissection based on the results of the sentinel node biopsy (1). There is no data on the role of neoadjuvant chemotherapy in MBC patients due to the small number of cases in individual centers. Hypothetically, accurate nodal status could allow consideration of downstaging the axilla in clinically node positive patients leading to limited axillary surgery with less morbidity if the negative predictive value was high. Neoadjuvant endocrine therapy and its role is unknown in males; however, accurate nodal information preoperatively could increase the opportunity for such a clinical trial. Further validation would be needed in patients who had negative axilla by radiomics if sentinel node biopsy could be omitted. As 50% of MBC patients are node negative, only 18–25% of MBC patients undergo SLN surgery alone or prior to axillary node dissection. Therefore, having an adjunct tool to predict nodal involvement that is non-invasive which can establish nodal status would be desirable.

There are limitations to our study as it is based on retrospective data. The mammography images are from three different centers however their acquisition protocol comparable. The distribution of images is 43% from facility 1, 33% from facility 2 and finally 23% from facility 3. Again, with MBC being such a rare disease, pooling data becomes essential. Some differences may be attributed to differences in imaging technique. Additionally, segmenting lesions manually can be another source of subjectivity that can affect the analysis. Since this study is a retrospective study, there was some demographic information that was not procured. Finally, due to the rarity of MBC, the number of cases are small compared to a study that would assess FBC.


Our pilot study suggests that a radiomics-based texture signature of the primary tumor is different between pathologically node negative vs. node positive male patients. Following validation radiomic features of the primary tumor could be a surrogate for nodal status. Our data merits further investigation in a larger sample size to confirm which patients could forego sentinel node biopsy and identifying additional biological-radiomic correlations to predict early on which MBC patients might be good candidates for neoadjuvant therapy.


Funding: None.


Reporting Checklist: The authors have completed the MDAR reporting checklist. Available at

Data Sharing Statement: Available at

Peer Review File: Available at

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at RK has a patent on breast cancer analysis, and is the CMO and Founder Imaging Endpoints Core Lab, the MIO for ImaginAB, and a consultant for Merrimack, Globavir, Verve, Dracon, TD2, and TGEN/City of Hope. VD is an Advisory Board Member for Deeptek and is a consultant for Radmetrix. The other authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013). The study was approved by the Western Institutional Review Board to exempt the ethics review with the exemption number (B4-Exemption-Moorthy). Informed consent was also waived.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See:


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doi: 10.21037/abs-20-103
Cite this article as: Moorthy A, Varghese B, Rajack S, Korn R, Cen S, Moorthy B, Duddalwar V. Predicting nodal status in male breast cancer using mammogram based radiomic metrics. Ann Breast Surg 2021;5:2.