@article{ABS5473,
author = {Michael Co and Vivian Man and Ava Kwong},
title = {Serum tumor markers and positron emission tomography-computed tomography scan as post-breast cancer treatment surveillance},
journal = {Annals of Breast Surgery},
volume = {3},
number = {0},
year = {2019},
keywords = {},
abstract = {Background: Post-operative surveillance is an important aspect in managing breast cancers. The primary aim is to allow early detection of metachronous breast cancers. However, post-operative breast cancer surveillance has not been standardized. Mammography has been the only evidence-based imaging modality for detecting metachronous breast cancers. The value of regular monitoring with serum carcinoembryonic antigen (CEA) and CA 15-3 has been controversial. The aim of this study is to evaluate the efficacy of using tumor markers as a surveillance tool in post-operative patients.
Methods: This is a retrospective review of all post-breast cancer surgery patients monitored with tumor markers from 2005–2010. Correlation between tumor markers and subsequent detection of metachronous breast cancer was evaluated. Long-term survival data was analyzed.
Results: Six hundred and forty-nine patients underwent positron emission tomography-computed tomography (PET-CT) scan, 250 patients had regular tumor markers monitoring. By using 5 ng/mL as cutoff for CEA, and 23 U/mL for CA 15.3, elevated levels are associated with development of metachronous breast cancer (P=0.004 and P},
issn = {2616-2776}, url = {https://abs.amegroups.org/article/view/5473}
}